1,8-cineole heals cutaneous pseudomoniasis in goats: An animal model study

1,8-cineole heals cutaneous pseudomoniasis in goats: An animal model study

Blog Article

Pseudomonas aeruginosa, an opportunistic bacterium is also an important pathogen in animals, resis-tant to various antibiotics in different ways.The purpose of the present study was to evaluate 1-8 cineole, a new antimicrobial agent derived from medicinal plants.Four male and female goats about two years of age weighing 45 kg were used.To prepare the P.aeruginosa inoculation site, a 30 cm2 area in the right and left flank and thorax region were shaved.

The inoculum was injected intrader-mally at five sites, with 0.4 mL in a concentration moondrop quarks of 106 CFU/mL of P.aeruginosa per site.After the induction of cutaneous pseudomoniasis, lesions in the right thoracic area were treated with 1-8 cineole, lesions in the left thoracic area treated with gentamicin ointment as a standard drug and le-sions in the right flank were treated with glycerin daily until complete recovery.Daily administration of cineole and gentamicin for nine days improved skin lesions.

Same as the untreated group (n=4), glycerin did not affect cutaneous lesions.The results of this study showed that 1,8-cineole, same as gentamicin, healed and improved cutaneous here lesions in goats caused by Pseudomonas infection within nine days.